Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones vi

Details Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones vi Process for preparing 3-amino-5-(pyridinyl)-2(1H)-pyridinones vi

1981-05-11

1982-07-13

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424263, 424266, C07D40104

Patent

active

043395848

ABSTRACT:
N-Hydroxy-1-R.sub.1 -1,2-dihydro-2-oxo-5-PY-6-R-nicotinimidamides or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonic agents, are prepared by reacting 1-R.sub.1 -1,2-dihydro-2-oxo-5-PY-6-R-nicotinonitriles with hydroxylamine and are converted by reaction with polyphosphoric acid to the corresponding cardiotonically useful 1-R.sub.1 -3-amino-5-PY-6-R-2(1H)-pyridinones, where R.sub.1 is hydrogen, lower-alkyl and lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.

REFERENCES:
patent: 3334137 (1967-08-01), Bruderlein
patent: 3720714 (1973-03-01), Bailey
patent: 3897447 (1975-07-01), Fisher et al.
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.

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