Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-01
1997-12-16
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 934, 530367, 530402, G01N 3353
Patent
active
056984057
ABSTRACT:
The immunogenicity of avidin, a therapeutic agent moiety of a conjugate, or a targeting composition is reduced by coupling the immunogenic agent with a carbohydrate polymer or polyol groups, such as polysaccharides (e.g. dextran), polyethylene glycol and the like.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4977288 (1990-12-01), Kassis et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5482698 (1996-01-01), Griffiths
Sinitsyn, et al. "Use of Avidin for Enhanced Blood Clearance of Biotinylated Immunoglobulins," Byull. Eksp. Biol. Med., 109:6 pp. 567-569 w/English abstract (1990) Russian Lang. Doc.
Paganelli, et al. "Tumor Targeting in Patients with Ovarian Cancer Using Biotinylated Monoclonal Antibodies and Radioactive Streptavidin," J. Nucl. Med., 31:5 p. 735 (May 1990); Abstract #117.
Hnatowich, et al. "Investigations of Avidin and Biotin for Imaging Applications," J. Nucl. Med., 28:8 pp. 1294-1302 (1987).
Kalofonos, et al. "Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communications," J. Nucl. Med., 31:11 pp. 1791-1796 (Nov. 1990).
Fuccillo, D.A. "Application of the Avidin-Biotin Technique in Microbiology," BioTechniques 3:5 pp. 494-501 (1985).
Osband et al., Immunology Today 11(6):193-195, 1990.
Harris et al., TIBTECH 11:42-44, 1993.
Gould et al., J. National Cancer Inst. 81(10):775-781, 1989.
Waldmann, Science 252:1657-1662, 1991.
Hermentin et al., Behring Inst. Mitt. 82:197-215, 1988.
CA 113(13):113321a and Sinitsyn et al., Byull Eksp. Biol. Med. 109(6):567-569, 1990.
Yoshikawa et al., J. Pharmcol. Expt. Ther. 263(2):897-903, 1992.
Lee et al., "Abrogation of reaginic antibodies with modified allergens," Nature 267:618-619, Jun. 16, 1977.
Kamisaki et al., "Reduction in Immunogenicity and Clearance Rate of Escherichia coli L-Asparaginase by Modification with Monomethoxypolyethyleneglycol," Journal of Pharm. and Exp. Therap. 216(2):410-414, 1981.
Abuchowski et al, "Effect of Covalent Attachment of Polyethylene Glycol on Immunogenicity and Circulating Life of Bovine Liver Catalase," J. of Biol. Chem. 252(11)3582-3586, Jun. 10, 1977.
Paganelli et al., "Three-Step Monoclonal Antibody Tumor Targeting . . . ," Cancer Research 51:5960-5966, Nov. 1991.
Immunomedics Inc.
Spiegel Carol A.
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