Human MLF3 protein

Details Human MLF3 protein Human MLF3 protein

1997-02-25

1998-12-22

Huff, Sheela

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 235, 530350, 530380, 514 44, 435 691, 435 693, 4353201, 4352523, C12Q 168, C07H 2100, C07H 2102, C07H 2104

Patent

active

058517740

ABSTRACT:
The present invention provides a novel human integral membrane (MLF3) and polynucleotides which identify and encode MLF3. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding MLF3 and a method for producing MLF3. The invention also provides for agonists, antibodies, or antagonists specifically binding MLF3, and their use, in the prevention and treatment of diseases associated with expression of MLF3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding MLF3 for the treatment of diseases associated with the expression of MLF3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding MLF3.

REFERENCES:
Kuefer et al., Gemonics vol. 35 p. 392, Jul. 1996.
Yoneda-Kato, N et al., "The t(3;5) (q25.1;134) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1" Oncogene 12(2):265-275 (1996) (GI 1066392 and GI 1066391).
Kuefer, MU et al., "cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2)" Genomics 35(2):392-396 (1996) (GI 1399745 and GI 1399744).
Schimmel, P., "Aminoacyl tRNA synthetases: general scheme of structure-function relationships in the polypeptides and recognition of transfer RNAs" Annu Rev Biochem 56:125-158 (1987).
Brenner, S., "The molecular evolution of genes and proteins: a tale of two serines" Nature 334 (6182):528-530 (1988).
Garber, GE et al., "A Trichomonas vaginalis cDNA with partial protein sequence homology with a Plasmodium falciparum excreted protein ABRA" Appl Parasitol 34(4):245-249 (1993).
Yoneda-Kato, N. et al., (Direct Submission), GenBank Sequence Database (Accession 1066392), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1066392) (1996).
Yoneda-Kato, N. et al., (Direct Submission), GenBank Sequence Database (Accession L49054), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1066391) (1996).
Kuefer, M.U. et al., (Direct Submission), GenBank Sequence Database (Accession 1399745), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1399745) (1996).
Kuefer, M.U. et al., (Direct Submission), GenBank Sequence Database (Accession U57342), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1399744) (1996).

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