Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-09-15
1997-12-16
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
436518, 436820, C12Q 170, G01N 33576
Patent
active
056983905
ABSTRACT:
A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses.
The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
REFERENCES:
patent: 4395395 (1983-07-01), Tabor et al.
patent: 4464474 (1984-08-01), Coursaget et al.
patent: 4659678 (1987-04-01), Forrest et al.
patent: 4673634 (1987-06-01), Seto et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4702909 (1987-10-01), Villarejos et al.
patent: 4891313 (1990-01-01), Berger et al.
patent: 5077193 (1991-12-01), Mishiro et al.
patent: 5106726 (1992-04-01), Wang
patent: 5191064 (1993-03-01), Arima et al.
patent: 5218099 (1993-06-01), Reyes et al.
patent: 5350671 (1994-09-01), Houghton et al.
patent: 5436126 (1995-07-01), Wang
patent: 5436318 (1995-07-01), Reyes et al.
Arrand, et al., "Molecular Cloning of the Complete Epstein-Barr Virus Genome as a Set of Overlapping Restriction Endonuclease Fragments," Nucleic Acids Res. 9(13):2999-3014 (1981).
Baer, et al., "DNA Sequence and Expression of the B95-8 Epstein-Barr Virus Genome," Nature 310:207-211 (1984).
Bankier, et al., "Sequence Analysis of the 17,166 Base-Pair Ecori Fragment C of B95-8 Epstein-Barr Virus," Mol. Biol. Med. 1:21-45 (1983).
Beck, et al., "Human Cytomegalovirus Encodes a Glycoprotein Homologous to MHC Class-I Antigens," Nature 331:269-272 (1988).
Mierendorf, et al., "Gene Isolation by Screening .lambda.gt11 Libraries With Antibodies," Methods In Enzymology, Ch. 51, 152, Berger & Kimmel (Eds.), Academic Press Ltd. (1987).
Biggin, et al., "Transcription and DNA Sequence of the BamHIL Fragment of B95-8 Epstein-Barr Virus," EMBO J. 3(5):1083-1090 (1984).
Billeter, et al., "Cloning of DNA Corresponding to Four Different Measles Virus Genomic Regions," Virology 132:147-159 (1984).
Blumberg, "Australia Antigen and Biology of Hepatitis B," Science 197:17-25 (1977).
Bodescot, et al., "Clustered Alternative Splice Sites In Epstein-Barr Virus Rnas," Nucleic Acids Res. 15:5887 (1987).
Boss, et al., "Cloning and Sequence Analysis of the Human Major Histocompatibility Complex Gene DC-3.beta.," Proc. Natl. Acad. Sci. USA 81:5199-5203 (1984).
Bradley, "Research Perspectives in Posttransfusion Non-A, Non-B Hepatitis," Infection, Immunity and Blood Transfusion, (Dodd, R.Y. & Barker, L.F. (Eds.), Alan R. Liss Inc.) pp. 81-97 (1985).
Bradley, et al., "Transmission, Etiology and Pathogenesis of Viral Hepatitis Non-A, Non-B in Non-Human Primates," Adv. Hepat. Res. Ch.31 pp. 268-280 (1984).
Bradley, et al., "Posttransfusion Non-A, Non-B Hepatitis: Physicochemical Properties of Two Distinct Agents," J. Infect. Dis. 148(2):254-265 (1983).
Burrell, et al., "Expression in Escherichia coli of Hepatitis B Virus DNA Sequences Cloned in Plasmid Pbr322," Nature 279:43-47 (1979).
Chan, et al., "Serological Responses to Infection with Three Different Types of Hepatitis C Virus," The Lancet 338:1391 (1991).
Charnay, et al., "Biosynthesis of Hepatitis B Virus Surface Antigen in Escherichia coli," Nature 286:893-895 (1980).
Daniels, et al., "A Second Major Class of Alu Family Repeated DNA Sequences in a Primate Genome," Nucleic Acids Res. 11(21):7595-7610 (1983).
Davies (ed.), Amino Acids and Peptides, (Chapman and Hall, London, 1985).
Davis, et al., "Isolation of cDNA Clones for Differentially Expressed Genes of the Human Parasite Schistosoma mansoni," Proc. Natl. Acad. Sci. USA 83:5534-5538 (1986).
Davison, et al., "The Complete DNA Sequence of Varicella-Zoster Virus," J. Gen. Virol. 67:1759-1816 (1986).
Deininger, et al., "Sequence Analysis and in Vitro Transcription of Portions of the Epstein-Barr Virus Genome," J. Cell Biochem. 19:267-274 (1982).
Dull, et al., "Insulin-Like Growth Factor II Precursor Gene Organization in Relation in Insulin Gene Family," Nature 310:777-781 (1984).
Emtage, et al., "Influenza Antigenic Determinants Are Expressed From Haemagglutinin Genes Cloned in Escherichia coli," Nature 283:171-174 (1980).
Farci, et al., "A Long-Term Study of Hepatitis C Virus Replication In Non-A, Non-B Hepatitis," New Eng. J. Med. 325(2):96-104 (1991).
Farrell, et al., "Latent and Lytic Cycle Promoters of Epstein-Barr Virus," EMBO J 2(8):1331-1338 (1983).
Farrell, et al., "Homologous Upstream Sequences Near Epstein-Barr Virus Promoters," Proc. Natl. Acad. Sci. USA 80:1565-1569 (1983).
Feinstone, et al., "Transfusion-Associated Hepatitis Not Due To Viral Hepatitis Type A Or B," New England J. Med. 292(15):767-770 (1975).
Forsgren, et al., "Molecular Cloning and Characterization of A Full-Length cDNA Clone for Hunman Plasminogen," FEBS Lett. 213(2):254-260 (1987).
Geysen, et al., "A Priori Delineation of A Peptide Which Mimics A Discontinuous Antigenic Determinant," Mol. Immunol. 23:709-715 (1986).
Gibson, et al., "Homology Between Two EBV Early Genes and HSV Ribonucleotide Reductase and 38K Genes," Nucleic Acids Res. 12(12):5087-5099 (1984).
Gilmore, et al., "The Nucleocapsid Gene of Infectious Hematopoietic Necrosis Virus, A Fish Rhabdovirus," Virology 167:644-648 (1988).
Glover (ed), DNA Cloning 1:A Practical Approach, (IRL Press, Washington DC, USA) (1985).
Gross, et al., (eds), The Peptides, (Academic Press, New York, 1983).
Houghton, et al., "Molecular Biology of the Hepatitis C Viruses: Implications for Diagnosis, Development and Control of Viral Disease," Hepatology 14:381-388 (1991).
Ishida, et al., "Sequence of 2,617 Nucleotides From the 3' End of Newcastle Disease Virus Genome RNA and the Predicted Amino Acid Sequence of Viral NP Protein," Nucleic Acids Res. 14(16):6551-6564 (1986).
Jeang, et al., "Organization of the Epstein-Barr Virus DNA Molecule. III. Location of the P3hr-1 Deletion Junction and Characterization of the Noti Repeat Units That Form Part of the Template for an Abundant 12-O-Tetradecanoylphorbol-13-Acetate-Induced mRNA Transcript," J. Virol. 48(1):135-148 (1983).
Jones, et al., "The EB Virus Genome In Daudi Burkitt's Lymphoma Cells Has A Deletion Similar To That Observed In A Non-Transforming Strain (P3HR-1) of the Virus," EMBO J. 3(4):813-821 (1984).
Kemp, et al., "Direct Immunoassay for Detecting Escherichia coli Colonies That Contain Polypeptides Encoded By Cloned DNA Segments," Proc. Natl. Acad. Sci. USA 78(7):4520-4524 (1981).
Kilejian, et al., "Histidine-Rich Domain of the Knob Protein of the Human Malaria Parasite Plasmodium falciparum," Proc. Natl. Acad. Sci. USA 83:7938-7941 (1986).
Kozak, "Possible Role of Flanking Nucleotides In Recognition of the AUG Initiator Codon By Eukaryotic Ribosomes," Nucleic Acids Res. 9(20):5233-5252 (1981).
Krissansen, et al., "Primary Structure of the T3 .gamma. Subunit of the T3/T Cell Antigen Receptor Complex Deduced From Cdna Sequences: Evolution of the T3 .gamma. and .delta. Subunits," EMBO J. 5(8):1799-1808 (1986).
Ladin, et al., "Characterization of A cDNA Encoding Ricin E, A Hybrid Ricin-Ricinus communis Agglutinin Gene From the Castor Plant Ricinus communis," Plant Mol. Biol. 9:287-295 (1987).
Laux, et al., "A Spliced Epstein-Barr Virus Gene Expressed In Immortalized Lymphocytes Is Created By Circularization of the Linear Viral Genome," EMBO J. 7(3):769-774 (1988).
Legouv et al., "Structure and Expression of the Murine L-Myc Gene," EMBO J. 6(11):3359-3366 (1987).
Malby, et al., "The Structure of A Complex Between the NC10 Antibody and Influenza Virus Neuraminidase and
Choo Qui-Lim
Houghton Michael
Kuo George
Blackburn Robert P.
Chiron Corporation
Harbin Alisa A.
Knode Marian C.
Monroy Gladys H.
LandOfFree
Hepatitis C immunoassays does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hepatitis C immunoassays, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatitis C immunoassays will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-204543