Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1996-01-26
1998-12-22
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4241841, 4241911, 530350, 5303871, 5303872, 5303881, 5303886, 530324, 530330, A61K 39012
Patent
active
058515356
ABSTRACT:
The invention relates to a polypeptide capable of reacting specifically with an anti-Toxoplasma gondii P30 protein antibody, and comprising a peptide sequence, in which any succession of 6 contiguous amino acids exhibits at most 67% homology with the peptide sequence of said P30 protein, identified by SEQ ID No.1, or comprising a sequence derived from said peptide sequence, and the applications of this polypeptide especially for detecting a Toxoplasma gondii infection, in a biological sample.
REFERENCES:
Isabelle Godard et al., "Antigenicity and Immunogenicity of P30-Derived Peptides in Experimental Models of Toxoplasmosis", Molecular Immunology, vol. 31, No. 17, pp. 1353-1363, 1994.
Brian G. Grimwood et al., "Toxoplasm Gondii: Purification of Trophozoites Propagated in Cell Culture", Experimental Parasitology, vol. 48, pp. 282-286, 1979.
Jamie K. Scott et al., "Searching for Peptide Ligands with an Epitope Library", Science, vol. 249, pp. 386-390, Jul. 1990.
J. Lawrence Burg et al, "Molecular Analysis of the Gene Encoding the Major Surface Antigen of Toxoplasma gondii", The Journal of Immunology, vol. 141, No. 10, pp. 3584-3591, Nov. 15, 1988.
H. Mario Geysen et al., "Strategies for Epitope Analysis Using Peptide Synthesis", Journal of Immunological Methods, vol. 102, pp. 259-274, 1987.
Lloyd H. Kasper et al., "Purification of a Major Membrane Protein of Toxoplasma Gondii by Immunoabsorption with a Monoclonal Antibody", The Journal of Immunology, vol. 130, No. 5, pp. 2407-2412, May 1983.
Benjamin J. Luft et al., "Toxoplasmic Encephalitis in Patients With Acquired Immune Deficiency Syndrome", JAMA, vol. 252, No. 7, pp. 913-917, Aug. 17, 1984.
H.P.A. Hughes, "Toxoplasmosis: The Need for Improved Diagnostic Techniques and Accurate Risk Assessment", Current Topics in Microbiology and Immunology, vol. 120, pp. 105-139, 1985.
Arthur E. Farkash et al., "CNS toxoplasmosis in Acquired Imune Deficiency Syndrome: A Clinical-Pathological-Radiological Review of 12 Cases", Journal of Neurology, Neurosurgery, and Pyschiatry, vol. 49, pp. 744-748, 1986.
Rolf H. Berg et al., "Long-Chain Polystyrene-Grafted Polyethylene Film Matrix: A New Support for Solid-Phase Peptide Synthesis", J. Am. Chem. Soc., vol. 111, pp. 8024-8026, 1989.
Bio Merieux
Housel James C.
Shaver Jennifer
LandOfFree
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