Method for destroying retinal pigment epithelial cells

Details Method for destroying retinal pigment epithelial cells Method for destroying retinal pigment epithelial cells

1998-01-28

2000-10-31

Ungar, Susan

Surgery

Miscellaneous

Methods

514 2, 514 8, 514 12, 514 21, 514 23, A61B 1900, A01N 3718, A01N 3800, A01N 4304

Patent

active

061386804

ABSTRACT:
A method for destroying retinal pigment epithelial cells in an eye in order to prevent the occurrence of proliferative vitreoretinopathy. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the vitreous chamber. The solution is maintained in the vitreous chamber for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes lining the vitreous chamber. The solution is then removed from the vitreous chamber, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the vitreous chamber, thereby exposing retinal pigment epithelial cells disposed on the basement membrane to the cytotoxic agent.

REFERENCES:
patent: 4920104 (1990-04-01), DeVore et al.
Nagasaki et al (Progress in Retinal and Eye Res., 17:77-98), 1998.
Handa et al (Current Eye Res., 15:1039-1044), 1996.
Burgess et al (J. Cell Bio., 111:2129-2138), 1990.

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