Maleic acid halfamides having blood pressure raising activity

Details Maleic acid halfamides having blood pressure raising activity Maleic acid halfamides having blood pressure raising activity

1978-12-13

1980-03-04

Helfin, Bernard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603405R, 26050111, 424319, 424282, 562401, 562444, A61K 3119, A61K 31205, C07C10120

Patent

active

041917774

ABSTRACT:
There are prepare half amides (semi-amides) of unsaturated aliphatic dicarboxylic acids of the formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of these together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or C.sub.1 -C.sub.4 alkyl groups and n is 0 or 1 and their salts with the proviso that in the case of the free acids N[2-(3-hydroxyphenyl)-2-hydroxyethyl]-maleic acid monoamide is excluded. The compounds have blood pressure raising activity and also have antidepressive activity.

REFERENCES:
patent: 2275809 (1942-03-01), Roberts
patent: 3222395 (1965-12-01), Schultz et al.
patent: 3576854 (1971-04-01), Felder et al.
patent: 4002666 (1977-01-01), Shirai et al.

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