Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-08-04
1996-05-21
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
5303886, C07K 1447
Patent
active
055191185
ABSTRACT:
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and appears to allow the cell to escape from p53-regulated growth.
REFERENCES:
Farharzadeh et al., "Tumorigenic Potential Associated with Enhanced Expression of a Gene That is Amplified in a Mouse Tumor Cell Line", The EMBO Journal 10(6):1565-1569 (1991).
Hinds et al., "Mutant p. 53 DNA Clones From Human Colon Carcinomas Cooperate With Ras in Transforming Primary Rat Cells: A Comparison of the `Hot Spot` Mutant Phenotypes", Cell Growth & Differentiation, 1:561-580 (1990).
Romkes et al., "Cloning and Expression of Complementary DNAs for Multiple Members of the Human Cytochrome P450IIC Subfamily", Biochemistry 30:3247-3255 (1991).
Oliner et al., "Amplification of a Gene Encoding a p. 53--Associated Protein in Human Sarcomas", Nature 358:80-83 (1992).
Oliner et al., "Oncoprotein MDM2 Conceals the Activation Domain of Tumor Suppressor p. 53", Nature 362(6423):857-860 (1993) Abstract.
Leach et al., "p. 53 Mutation and MDM2 Amplification in Human Soft Tissue Sarcomas", Cancer Research 53:2231-2234 (1993).
Momand et al., "The mdm-2 Oncogene Product Forms a Complex With the p. 53 Protein and Inhibits p. 53--Mediated Transactivation", Cell 89:1237-1245 (1992).
Bueso-Ramo et al., "The Human MDM2 Oncogene is Overexpressed in Leukemias", Blood, 2(9):2017-2023 (1993).
Kinzler Kenneth
Vogelstein Bert
Fleisher Mindy
McKelvey Terry A.
The Johns Hopkins University
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