Alkanoic acid derivatives as .alpha.v integrin receptor antagoni

Details Alkanoic acid derivatives as .alpha.v integrin receptor antagoni Alkanoic acid derivatives as .alpha.v integrin receptor antagoni

1999-08-10

2000-07-18

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514218, 514252, 514299, 514300, 514340, 514390, 514392, 540492, 544284, 546122, 546134, 546274, 546 4, 546300, 5462777, 5483047, 5483235, 5483245, 5483251, C07D47102, C07D45302, C07D40106, A61K 314375, A61N 1908, A61N 1910

Patent

active

060909447

ABSTRACT:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3, .alpha.v.beta.5 and/or .alpha.v.beta.6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, and tumor growth and metastasis.

REFERENCES:
patent: 5455243 (1995-10-01), Duggan et al.

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