Substituted aminothienopyridines, pharmaceutical composition and

Details Substituted aminothienopyridines, pharmaceutical composition and Substituted aminothienopyridines, pharmaceutical composition and

1993-10-06

1996-05-21

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546114, 514307, A61K 3144, C07D49504

Patent

active

055190324

ABSTRACT:
This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.

REFERENCES:
patent: 2811527 (1957-10-01), Sheehan
patent: 5252581 (1993-10-01), Effland et al.
Klemm et al., Journal of Het. Chem., vol. 7, (1970), pp. 373-379.
Klemm et al., Journal of Het. Chem., vol. 12, (1975), pp. 1183-1186.
Klemm et al., Journal of Het. Chem., vol. 14, (1977), pp. 290-303.
Guerrera et al., II. Farmaco, Ed. Sci., vol. 31, (1976), pp. 21-30.
Gronowitz et al., Arkiv For. Kemi, vol. 32 (1970), pp. 249-268.
Horn, Journal of Neurochemistry, vol. 21 (1973), pp. 883-888.
Fiegliner, Journal of Clinical Psychopharmacology, Suppli., vol. 1 (1981) pp. 235-265.
Traber et al, Trends in Pharmacological Sciences, vol. 8 (1987), pp. 432-437.

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