Substituted alpha-aminosulphonyl-acetohydroxamic acids as therap

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514451, 514461, 514467, 514520, 514821, 514824, 514825, 549426, 549451, 549491, 562621, 562623, 558411, A61K 3116, C07C23908

Patent

active

060908521

ABSTRACT:
Compounds of formula (I): ##STR1## where the substituents are as defined herein, and salts thereof, are matrix metalloprotease inhibitors.

REFERENCES:
patent: 5932595 (1999-08-01), Bender et al.
Beckett, R.P., et al., 1996, DDT 1(1):16-26, "Recent advances in matrix metalloproteinase inhibitor research".
Beckett, R.P., 1996, Exp. Opin. Ther. Patents 6(12):1305-1315, "Recent advances in the field of matrix metalloproteinase inhibitors".
Zask, A., et al., 1996, Curr. Pharm. Design 2:624-661, "Inhibition of matrix metalloproteinases: structure based design".

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