Use of an NADPH-oxidase inhibitor in the treatment of reperfusio

Details Use of an NADPH-oxidase inhibitor in the treatment of reperfusio Use of an NADPH-oxidase inhibitor in the treatment of reperfusio

1998-09-09

2000-07-18

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514689, 514699, 514717, 514731, A61K 3119, A61K 3112, A61K 3111, A61K 31075, A61K 3105

Patent

active

060908513

ABSTRACT:
The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of an NADPH-oxidase inhibitor to a cell, tissue, organ or animal in an amount sufficient to treat the cell, tissue, organ or animal for reperfusion injury prophylactically or therapeutically. The NADPH-oxidase inhibitor preferably is an o-methoxycatechol, or a pharmaceutically acceptable salt, derivative, dimer or prodrug thereof. Most preferably, the o-methoxycatechol is apocynin.

REFERENCES:
patent: 5763496 (1998-06-01), Holland
Das et al., Journal of Biological Chemistry, 267(27), 19172-19178(1992).
Domany et al., Pharmazie, 49, 807-810 (1994).
Shibuya et al., Hepatology, 25(2), 356-360 (1997).
Wang et al., Hepatology, 15(6), 1112-1116 (1992).
Engels et al., FEBS Letters, 305(3), 254-256 (1992).
Pearse et al., Am. J. Respir. Crit. Care Med., 153, 196-202 (1996).
t'Hart et al., Biotech Therapeutics, 3(3 and 4), 119-135 (1992).

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