EP.sub.2 -receptor agonists as neuroprotective agents for the ey

Details EP.sub.2 -receptor agonists as neuroprotective agents for the ey EP.sub.2 -receptor agonists as neuroprotective agents for the ey

1998-11-03

2000-07-18

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514513, 514912, A61K 31215

Patent

active

060908475

ABSTRACT:
The invention relates to the use of EP.sub.2 receptor agonists as neuroprotective agents. In particular said compounds are represented by the formulae: ##STR1## wherein the broken line attachment to the cyclopentane ring or the omega chain indicates the .alpha. configuration and the solid line attachment to the cyclopentane ring or the omega chain indicates the .beta. configuration, R is hydrogen or a saturated or unsaturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or --(CH.sub.2).sub.m R.sub.1 wherein m is 0-10, and R.sub.1 is an aliphatic ring having from about 3 to about 7 carbon atoms, or an aryl or heteroaryl ring having from about 4 to about 10 carbon atoms and wherein the heteroatom is selected from the group consisting of N, O and S.

REFERENCES:
patent: 5462968 (1995-10-01), Woodward
patent: 5698598 (1997-12-01), Woodward
Woodward et al, "The Molecular Biology and Ocular Distribution of Prostanoid Receptors", Survey of Ophthalmology, vol. 41, Supplement 2, Feb. 1997, pp. 515-521.
Akaike et al, "Prostaglandin E.sub.2 protects cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity", Brain Research 663 (1994), pp. 237-243.
Woodward et al, "Molecular Characterization and Ocular Hypotensive Properties of the Prostanoid EP.sub.2 Receptor", Journal of Ocular Pharmacology and Therapeutics, vol. 11, No. 3, 1995, pp. 447-454.

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