Process for producing optically active 3-aminobutanoic acid and

Details Process for producing optically active 3-aminobutanoic acid and Process for producing optically active 3-aminobutanoic acid and

1994-08-11

1996-05-21

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435195, 435196, 435197, 435198, 435280, C12P 4100, C12N 914, C12N 916

Patent

active

055189032

ABSTRACT:
The present invention provides a process for producing optically active 3-aminobutanoic acid characterized in that it comprises an asymmetrically hydrolyzing racemic ester of 3-substituted aminobutanoic acid in the presence of a hydrolase, obtaining an optically active ester of 3-substituted aminobutanoic acid and an optically active 3-substituted aminobutanoic acid of an enantiomer of the ester, and treating the above ester represented by the formula (II): ##STR1## to remove the protecting group. In addition, the new ester intermediates represented by the above formula (II) are provided.

REFERENCES:
Davis et al., Tetrahedron: Asymmetry, vol. 2, No. 3, pp. 183-1986 (1991).
Lubell et al., Tetrahedron: Asymmetry, vol. 2, No. 7, pp. 543-554 (1991).
Juaristi et al., J. Org. Chem., vol. 57, No. 8 (1992) pp. 2396-2398.
Hunt et al., J. Biol. Chem., vol. 127, pp. 727-735 (1939).
Fischer et al., Liebigs Ann. Chem., vol. 383, pp. 337-363 (1911).
Rossi et al., Experientia, vol. 33, pp. 1557-1559 (1977).
Gmeiner, Liebigs Ann. Chem., pp. 501-502 (1991).
Jefford et al., Tetrahedron Letters, vol. 34, No. 7, pp. 1111-1114 (1993).
Estermann et al., Helvetica Chemica Acta., vol. 71, pp. 1824-1839 (1988).

Affiliated with

Also associated with

Rating

Process for producing optically active 3-aminobutanoic acid and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing optically active 3-aminobutanoic acid and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing optically active 3-aminobutanoic acid and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2037303