Cardioactive factor

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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Details

424101, 260112R, A61K 3700, A61K 3514

Patent

active

043394418

ABSTRACT:
A proteinaceous cardioactive factor that exhibits positive inotropic activity and positive chronotropic activity has been partially extracted from mammalian plasma by precipitation with polyethylene glycol followed by cation exchange chromatography. The factor may be fractionated into two active fractions, one having an apparent molecular weight of about 130,000 daltons and the other having an apparent molecular weight of about 30,000 daltons, by gel filtration chromatography.

REFERENCES:
patent: 4237046 (1980-12-01), Bodanszky

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