Transdermal delivery system for estradiol and process for manufa

Details Transdermal delivery system for estradiol and process for manufa Transdermal delivery system for estradiol and process for manufa

1993-03-02

1996-05-21

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1300

Patent

active

055187340

ABSTRACT:
The present invention relates to a transdermal delivery device for estradiol where the metabolic degradation of estradiol to estrone during permeation is inhibited by another substance in the transdermal delivery device. The transdermal device also includes a compound for enhancing the rate of estradiol permeation. The transdermal delivery device containing the inhibitor and enhancer can also be used to simultaneously deliver both estradiol and a progestin at therapeutic rates.

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Chien, Y-W, "Developmental Concepts and Practice in Transdermal Therapeutic Systems," Transdermal Controlled systemic Medications, Marcel Dekker, Inc., Chapter 2: 25-81.
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Biological Abstracts, vol. 88, nr. 1, 1989, abstract nr 9062, Philadelphia, PA, US; Goodman et al.: "Action of penetration enhancers on skin as assessed by the permeation of model drug 5-fluorouracil and estrdiol", & J. Invest. Darmatol. 91(4): 323-327, 1988.
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