Method for the preparation of anti-receptor antibodies

Details Method for the preparation of anti-receptor antibodies Method for the preparation of anti-receptor antibodies

Filed on

1984-05-24

Date issued

1987-07-28

Examiner

Kight, John

Patent Class

Chemistry: natural resins or derivatives; peptides or proteins;

SubClass

Proteins, i.e., more than 100 amino acid residues

SubSubClass

Blood proteins or globulins, e.g., proteoglycans, platelet...

Other Related Categories

530387, 530388, 424 85, 436547, 436548, 435 68, C07K 308

Type

Patent

Status

active

Patent number

046832955

Description

ABSTRACT:
A method is discussed for the production of anti-receptor antibodies and to the detection and isolation of naturally occurring anti-receptor antibodies in animals and humans. The anti-receptor antibodies can be isolated from polyvalent anti-receptor antisera by immunodepletion of anti-immunoglobulin antibodies or by a single affinity purification step using antibody raised to an antigen recognized by the receptor.

REFERENCES:
patent: 4513088 (1985-04-01), Levy et al.
patent: 4536479 (1985-08-01), Vander-Mallie
patent: 4545986 (1985-10-01), Malley
Strasburg, "Anti-Idiotype and Anti-Hormone Receptor Antibodies", Springer Semin Immunopathal, 6, 1983, pp. 67-78.
Kull et al, "Monoclonal Antibodies of Receptors for Insulin and Somatomedins-C", IBC, 258(10), 1983, pp. 6561-6566.
Couraud et al, "Immunological Statistics of P-Adrinergic Receptors", I. Cellular Biochem, 21, 1983, pp. 187-193.
Fraser et al, "Monoclonal Antibodies to P-Adrenergic Receptors", PNAS, 77(12), 1980, pp. 7034-7038.
Venter et al, "B-Adrenergic Receptor . . . Monoclonal Antibodies", Fed Proc, vol. 42(2), 1983, pp. 273-278.
Venter et al, "Monoclonal and Anti-Idiotypic Antibodies . . . Function", Fed Proc, vol. 43(10), 1984, pp. 2532-2539.
Forstrom et al, "Immunization up to a Synergies Sarcoma by Monoclonal . . . Antibody", Nature 303, 1983, pp. 627-629.

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