Interferon responsive transcript (IRT-1)

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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43525233, 435325, 4353201, 530350, 536 231, 536 235, C12P 2106, C07H 2104

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060905808

ABSTRACT:
An isolated transcribed nucleotide sequence, termed interferon Responsive Transcript -1 (IRT-1), encodes a deduced 132 amino acid basically-charged protein. The invention is directed to IRT-1 nucleic acid, its structural and functional homologs, including portions of the nucleotide, and complements of the nucleotide sequence. Also provided are isolated amino acid sequences encoded by the IRT-1 nucleotide sequences, structural and functional homologs of the isolated amino acid sequences, including portions of the amino acid sequences and antibodies to the amino acid sequences. The IRT-1 nucleic acid sequences may be used to detect and produce other sequences, to regulate or oppose production of vascular smooth muscle cells, and to prevent or treat proliferative arterial disease and/or vascular restenosis.

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