Fluoroalkyl esters of dihydrolysergic acid useful as 5HT.sub.2 r

Details Fluoroalkyl esters of dihydrolysergic acid useful as 5HT.sub.2 r Fluoroalkyl esters of dihydrolysergic acid useful as 5HT.sub.2 r

1985-12-20

1987-07-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 68, 546 69, A61K 3148, C07D45704

Patent

active

046832378

ABSTRACT:
Mono, difluoro or trifluoroalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)-ergoline-8.beta.-carboxylic acid, useful as 5HT.sub.2 receptor antagonists.

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Lemberger et al., Life Sci., 35, 71 (1984).
Cohen et al., Drug Dev. Res., 5, 313 (1985).
Hingten et al., Abstract 37.4, Soc. for Neurosci. (13th Annual Meeting, Nov., 1983).

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