Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1995-11-08
2000-07-18
Duffy, Patricia A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 791, 435 24, 436 63, 436 69, G01N 3386, C12Q 156
Patent
active
060905700
ABSTRACT:
Method for specifically detecting a coagulation factor V which has an increased stability toward activated protein C in the activated state.
REFERENCES:
patent: 5051357 (1991-09-01), Hassouna
Sun et al., "Blood Coagulation Factor Va Abnormality Associated With Resistance to Activated Protein C in Venous Thrombosis" Blood 83, 3120-3125 (1994). See Materials and Methods.
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M.E. Rick et al., "Factor IXa and von Willebrand Factor Modify The Inactivation of Factor VII by Activated Protein C", J. Lab. Clin. Med., 115(4):415-421 (1990).
L. Amer et al., "Impairment of The Protein C Anticoagulant Pathway in a Patient With Systemic Lupus Erythematosus, Anticardiolipin Antibodies and Thrombosis", Thromb. Res., 57(2):247-258 (1990).
R.M. Bertina et al., "Mutation in Blood Coagulation Factor V Associated With Resistance to Activated Protein C", Nature, 369, p. 64-67 (1994).
P. Thiagarajan et al., "The Use of the Dilute Russell Viper Venom Time For Diagnosis of Lupus Anticoagulants", Blood, 68(4):869-874 (1986).
S. Horie et al., "Enhancement of Thrombin-Thrombomodulin-Catalysed Protein C Activation By Phosphatidylethanolamine Containing Unsaturated Fatty Acids: Possible Physiological Significance of Phosphatidylethanolamine in Anticoagulant Activity of Thrombomodulin", Biochem. J., 301, p. 683-691 (1994).
J. Rosing et al., "Inventory of Exogenous Prothrombin Activators", Thrombosis and Haemostatis, 65(5):627-630 (1991).
Bertina et al., "Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C," Nature 369:64-67 (1994).
Karges et al., "Activity of Coagulation and Fibrinolysis Parameters in Animals," Arzneim.-Forsch/Drug Res. 44(1) (6):793-97 (1994).
Kraus et al., "Coagulation Assay with Improved Specificity to Factor V Mutants Insensitive to Activated Protein C," Thrombosis Res. 80(3):255-64 (1995).
Dade Behring Marburg GmbH
Duffy Patricia A.
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