Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-02
2000-07-18
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 436 63, 436 64, G01N 33574, G01N 3353, G01N 3348
Patent
active
060905662
ABSTRACT:
Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. Loss of wild-type p53 genes is responsible for neoplastic progression.
REFERENCES:
Crawford et al "Human p53 and human tumours" BioEssays, vol. 3, No. 3, pp. 117-120, Sep. 1985.
Cattoretti et al, "p53 expression in breast cancer", Int. J. Cancer, vol. 41, pp. 178-183, Feb. 15, 1988.
Crawford et al, "The cellular protein p53 in human tumours", Mol. Biol. Med., vol. 2, pp. 261-272, Aug. 1984.
Crawford et al, "Detection of a common feature in several human tumor cell lines-a 53,000-dalton protein", PNAS, vol. 78, pp. 41-45, Jan. 1981.
Baker Suzanne J.
Fearon Eric R.
Nigro Janice M.
Vogelstein Bert
Eyler Yvonne
Johns Hopkins University
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