Chroman esters of phenols and benzoic acids having retinoid-like

Details Chroman esters of phenols and benzoic acids having retinoid-like Chroman esters of phenols and benzoic acids having retinoid-like

1989-12-29

1991-04-09

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549405, A61K 3135, C07D31104

Patent

active

050065505

ABSTRACT:
Retinoid like activity is exhibited by compounds of the formula ##STR1## wherein the R.sub.1 -R.sub.7 groups are independently H or straight chain or branched chain lower alkyl or cycloalkyl of 1 to 6 carbons; X symbolizes an ester or thioester linkage, Y is cycloalkyl or branched chain alkyl of 1 to 6 carbons or is (CH.sub.2) where n is an integer between 0 to 6 or is an alkenyl group of 2 to 6 carbons, or an alkynyl group of 2 to 6 carbons; and Z is H, OH, OR', OCOR', --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR' or a ketal derivative where R' is an alkyl, cycloalkyl or alkenyl group containing 1 to 6 carbons, or a phenylalkyl, phenyl or substituted phenyl group.

REFERENCES:
patent: 4739098 (1988-04-01), Chandraratna
patent: 4740519 (1988-04-01), Shroot et al.
Taguchi et al., C.A., 92:85928f (1980)-Abstract of Japan Kokai Tokkyo Koho 7995233 (7/27/79).
Sporn et al., in J. Amer. Acad. Derm., 15:756-764 (1986).
Shudo et al., in Chem. Phar. Bull., 33:404-407 (1985).
Kagechika et al., in J. Med. Chem., 31:2182-2192 (1988).

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