2-aryl-3-(substituted piperazinyl)-1-(1H-1,2,4-triazolyl)propano

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514252, 514253, 5142282, 5142338, 5142352, 5142362, 544366, 544121, 544 586, 544363, 544368, 544364, A01N 4360, C07D40114, C07D41314, C07D41714

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active

048852945

ABSTRACT:
An antifungal agent of the formula: ##STR1## wherein R is phenyl group which may be substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ; R.sup.1 is either (a) a phenyl group substituted by a group of the formula --N.dbd.CH--N(C.sub.1 -C.sub.4 alkyl).sub.2, ##STR2## or (b) a 5- or 6-membered aromatic heterocyclic group which may be benzo-fused and substituted by 1 or 2 substituents each independently selected from halo, C.sub.1 -C.sub.4 alkyl and halo-(C.sub.1 or C.sub.2 alkyl), said heterocyclic group being attached to the nitrogen atom of the piperazine ring by a carbon atom;

REFERENCES:
patent: 4738962 (1988-04-01), Holmwood et al.
Holmwood et al., Chemical Abstracts, vol. 105, entry 220995e (1986).

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