N-heterocyclic alcohol renin inhibitors

Details N-heterocyclic alcohol renin inhibitors N-heterocyclic alcohol renin inhibitors

1989-06-29

1989-12-05

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 5142358, 514252, 514332, 514333, 514336, 514357, 514365, 514367, 514374, 514375, 514394, 514395, 514397, 514398, 514400, 514406, 514407, 514422, 514424, 514427, 540544, 540553, 540575, 540597, A61K 3155, C07D41312

Patent

active

048852929

ABSTRACT:
Compounds of the formula ##STR1## are disclosed wherein R.sub.1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.

REFERENCES:
patent: 4599198 (1986-02-01), Hoover
patent: 4698329 (1987-10-01), Matsueda et al.
Burger, Medicinal Chem., 2nd Ed., Interscience, New York, 1960, pp. 551-564, 572-578, 582-599, and 602-620.
Rosenberg, S. et al., J. Med. Chem., 1987, vol. 30, pp. 1224-1228.
Burger, A. (editor), Medicinal Chemistry, 2nd ed., Interscience, New York, 1960, pp. 565-571, 579-581 and 600-601.

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