Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1987-12-01
1989-12-05
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 86, 514 89, 514 91, 514 93, 514 92, 514 94, 514119, 540463, 540487, 544 93, 544232, 548112, 548413, 562 15, A61K 31675, C07F 930
Patent
active
048852830
ABSTRACT:
The invention relates compounds of the formula ##STR1## wherein R.sup.1 -R.sup.5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase and can be used in the form of medicaments for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis.
REFERENCES:
patent: 4226610 (1980-10-01), Takematsu et al.
Broadhurst Michael J.
Handa Balraj K.
Johnson William H.
Lawton Geoffrey
Machin Peter J.
Bond Robert T.
Hoffmann-La Roche Inc.
Isgro William G.
Leon Bernard S.
Saxe Jon S.
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