Novel 14-amino steroids

Details Novel 14-amino steroids Novel 14-amino steroids

1988-09-30

1989-12-05

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 5, 540106, 540118, 514172, C07J 100, C07J 4100, C07J 1700, A61K 3158

Patent

active

048852805

ABSTRACT:
The invention relates to androstane-17-carboxylic acid esters, represented by general formula (I): ##STR1## wherein R.sub.1 represents a lower alkyl group containing 1 to 4 carbon atoms, a lower alkyl group containing 2 to 4 carbon atoms substituted by an amino group, or an aralkyl group from 6 to 12 carbon atoms, R.sub.2 and R.sub.3, which may be the same or different, represent a hydrogen atom or a lower alkyl group containing 1 to 4 carbon atoms, R.sub.4 represents a hydrogen atom, a hydroxy group or an acetoxy group, R.sub.5 represents a hydroxy or acetoxy group, or R.sub.4 and R.sub.5 represent together a divalent alkylenedioxy group, R.sub.6 represents a hydroxy group, a methoxy group, or an acetoxy group, R.sub.7 represents a methyl group or a hydroxymethyl group, R.sub.8 represents an hydrogen atom or a hydroxy group and ##STR2## represents either a ##STR3## group or a ##STR4## carbon atom having the double linkage in the 4- or 5-position of the steroid nucleus.
Such esters are prepared by coupling reaction of the corresponding 14-azido-derivatives with a sugar, followed by a reduction.
Application in therapy, especially in the treatment of heart failure.

REFERENCES:
patent: 3449381 (1969-06-01), Bowers
patent: 3634409 (1972-01-01), Cross
patent: 4552868 (1985-11-01), Jarreau

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