Temperature sensitive reassortant viruses and a vaccine against

Details Temperature sensitive reassortant viruses and a vaccine against Temperature sensitive reassortant viruses and a vaccine against

1984-07-26

1987-07-28

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Lymphokine

435236, 435235, 435239, A61K 2300, A61K 3912, A61K 39145, C12N 700

Patent

active

046831371

ABSTRACT:
This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37.degree.-39.degree. C., preferably 37.degree.-38.degree. C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.

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