HIV envelope polypeptides and vaccine

Details HIV envelope polypeptides and vaccine HIV envelope polypeptides and vaccine

1997-07-08

2000-07-18

Eisenschenk, Chris

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241841, 4241881, 4242041, 530395, 530350, 530326, 530327, 530329, A61K 3921, A61K 3912, A61K 3900, A61K 3938

Patent

active

060903929

ABSTRACT:
Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.

REFERENCES:
Berman et al., "Genetic and Immunologic Characterization of Viruses Infecting MN-rgp120 Vaccinated Volunteers," One World, One Hope: XI International Conference on AIDS, 10:3:10 (Jul. 7-12, 1996).
Berman et al., "Genetic and Immunologic Characterization of Viruses Infecting MN-rpg120-Vaccinated Volunteers," The Journal of Infectious Diseases, 176:2:384-397 (Aug., 1997).
McElrath et al., "Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen," Proc. Natl. Acad. Sci. USA, 93:3972-3977 (Apr., 1996).
Kitchen et al., "Aetiology of AIDS--Antibodies to Human T-cell Leukaemia Virus (Type III) in Haemophiliacs," Nature 312:367-369 (Nov. 22, 1984).
Moore, "Enhanced: Coreceptors--Implications for HIV Pathogenesis and Therapy," Science 276:51 (1996).
Vandenbark et al., "Immunization with a Synthetic T-cell Receptor V-region Peptide Protects Against Experimental Autoimmune Encephalmyelitis," Nature 341:541-544 (Oct. 12, 1989).

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