Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1998-07-28
2000-07-18
Mertz, Prema
Drug, bio-affecting and body treating compositions
Lymphokine
530351, 435 695, 435 712, 435471, 435325, 4352523, 4353201, 536 235, C12N 1519, C07K 1452, A61K 3819
Patent
active
060903775
ABSTRACT:
The present invention provides novel monocyte activating cytokine (MAC) and a polynucleotide encoding MAC. The invention also provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MAC. The invention also provides for the production and use of substantially purified MAC in pharmaceutical compositions for the treatment of cancer and disease of the immune system. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding MAC and antibodies which specifically bind to MAC.
REFERENCES:
Kao, et al., "Characterization of a Novel Tumor-derived Cytokine," J. Biol. Chem., vol. 269(40), pp. 25106-25119, 1994.
Ribas de Pouplana et al., "Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria," Proc. Nat'l. Acad. Sci. USA, vol. 93, pp. 166-170, 1996.
Kao et al., "A Peptide Derived from the Amino Terminus of Endothelial-Monocyte-activating Polypeptide . . . ," J. Biol. Chem., vol. 269(13), pp. 9774-9782, 1994.
Au-Young Janice
Bandman Olga
Coleman Roger
Murry Lynn E.
Incyte Pharmaceuticals Inc.
Mertz Prema
Price Leanne C.
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