Copolymers and their use as contrast agents in magnetic resonanc

Details Copolymers and their use as contrast agents in magnetic resonanc Copolymers and their use as contrast agents in magnetic resonanc

1995-06-07

1996-05-21

Acquah, Samuel A.

Surgery

Truss

Pad

528272, 528275, 528277, 528280, 528296, 528302, 528332, 528350, 528351, 528353, 528367, 562623, 556 1, 534 16, 424 9341, 424 935, 424 936, A61B 505

Patent

active

055179932

ABSTRACT:
Novel compounds having use as contrast agents in magnetic resonance imaging, as well as other uses, are described. The compounds are comprised of a copolymer which comprises at least two of a first monomer of the formula X.sub.1 -(CHR.sub.2 CHR.sub.2 --Y).sub.n --(CHR.sub.2).sub.m --CHR.sub.2 CHR.sub.2 --X.sub.2, wherein X.sub.1 and X.sub.2 are, independently, OH, NH.sub.2, NHR.sub.1, COOH, COOR.sub.1, SH, or Z, Y is O, NH, NR.sub.1, S, or CO, n is 0-10,000, m is 0 or 1, each Z is, independently, Cl, Br, or I, each R.sub.1 is, independently, a C.sub.1 -C.sub.20 substituted alkyl or cycloalkyl, and each R.sub.2 is, independently, H or OH, and at least one of a second monomer which is a polynitrilo chelating agent having at least two COOH, COOR.sub.1, or COZ groups, the first and second monomers being bound to one another to form a copolymer through an ester, amide, or carboxylic thioester linkage of at least one of the OH, NH.sub.2, NHR.sub.1, COOH, COOR.sub.1, SH or Z groups of the first monomer, and at least one of the COOH, COOR.sub.1, or COZ groups of the second monomer. Optionally, the copolymer may also include at least one of a third monomer which is a targeting agent or a targeting agent ligand having an OH, NH.sub.2, NHR.sub.1, COOH, COOR.sub.1, SH, or COZ group, wherein R.sub.1 is described as above, and wherein the third monomer is also bound with the first and second monomers to form a copolymer through an ester, amide, or carboxylic thioester linkage. For magnetic resonance imaging, for example, the copolymer may further comprise a paramagnetic ion chelated to the chelating agent.

REFERENCES:
patent: 2831885 (1958-04-01), Kroll et al.
patent: 3058948 (1962-10-01), Mosimann et al.
patent: 3859337 (1975-01-01), Herz et al.
patent: 4457870 (1984-07-01), Schroder et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
patent: 4729892 (1988-03-01), Beall
patent: 4730066 (1988-03-01), White
patent: 4746507 (1988-05-01), Quay
patent: 4822594 (1989-04-01), Gibby
patent: 4826673 (1989-05-01), Dean et al.
patent: 4830716 (1989-05-01), Ashmead
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 4888032 (1989-12-01), Busch
patent: 4916246 (1990-04-01), Felder et al.
patent: 4933441 (1990-06-01), Gibby
patent: 4933456 (1990-06-01), Rocklage et al.
patent: 4935518 (1990-06-01), Rocklage et al.
patent: 4952289 (1990-08-01), Ciccone et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4978763 (1990-12-01), Rocklage et al.
Runge, et al., "Paramagnetic Contrast Agents in Magnetic Resonance Imaging: Research at Vanderbilt University", Physiol. Chem. Phys. Med. NMR, (1984), 16, 113-122.
Tscholakoff, et al., "MR Imaging in the Diagnosis of Pancreatic Disease", AJR, (1987), 148, 703-709.
Wesbey, et al., "Nuclear Magnetic Resonance Contrast Enhancement Study of the Gastrointestinal Tract of Rats and a Human Volunteer using Nontoxic Oral Iron Solutions", Radiology, (1983), 149, 175-180.
Wesbey, et al., "Dilute Oral Iron Solutions as Gastrointestinal Contrast Agents for Magnetic Resonance Imaging; Initial Clinical Experience", Magn. Reson. Imaging, (1985), 3, 57-64.
Weinreb, et al., "Improved MR Imaging of the Upper Abdomen with Glucagon and Gas", J. Comput. Assist. Tomogr., 8, (1984), 835-838.
Widder, et al., "Magnetite Albumin Suspension: A Superparamagnetic Oral MR Contrast Agent", AJR, (1987), 149, 839-843.
Williams, et al., "Nonabsorbable Iron Preparations as Gastrointestinal Contrast Agents for MR Imaging: Preliminary Investigations", Radiology, (1986), 161, 315.
Young, et al., "Enhancement of Relaxation Rate with Paramagnetic Contrast Agents in NMR Imaging", CT, (1981), 5, 543.
Clanton, et al., "The Use of Oral Contract and Respiratory Gating in MR Imaging of the Pancrease", Radiology, (1984), 153, 159.
Clanton, et al., "Techniques Employees in NMR Imaging Using Oral Contrast Agents", Radiology, (1983), 149, 238.
Hahn, et al., "Imaging Artifacts Introduced by NRI Gastrointestinal Contrast Agents: Magnitude, Cause and Amelioration", Magn. Reson. Imaging, (1988), 6, 78.
Hahn, et al., "Ferrite Particles for Bowel Contrast in MR Imaging: Design Issues and Feasibility Studies", Radiology, (1987), 164, 37-41.
Kornmesser, et al., "Gastrointestinal Contrast Enhancement in MRI: First Clinical Experience with Gadolinium-DTPA", Magn. Reson. Imaging, (1988) 6, 124.
Laniado, et al., "MR Imaging of the Gastrointestinal Tract: Value of Gd-DTPA", AJR, (1988), 150, 817-821.
Mattrey, et al., "Perfluorochemicals as Gastrointestinal Contrast Agents for MR Imaging", AJR, (1988), 148, 1259-1263.
Newhouse, et al., "NMR Imaging Preliminary Results in the Upper Extremities of man and the Abdomen of Small Animals", Radiology, (1982), 142, 246.
Runge, et al., "Work in Progress: Potential Oral and Intravenous Paramagnetic NMR Contrast Agents.sup.1 ", Radiology, (1983), 147, 789-791.

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