Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1982-09-30
1984-05-01
Lesmes, George F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424355, A61K 3100, A61M 514
Patent
active
044461550
ABSTRACT:
A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischmeic and other diseased neurologic tissue during treatment are provided.
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Peerless et al., "Protective Effect of Fluosol-DA in Acute Cerebral Ischemia", Stroke, vol. 12, No. 5, pp. 558-563, (1981).
Reulen, et al., "Clearance of Edema Fluid into Cerebrospinal Fluid", J. Neurosurg 48: 754-764, (1978).
Schutz, et al., "Brain Mitochondrial Function After Ischemia and Hypoxia", Arch Neurol, vol. 29, pp. 417-419, (Dec. 1973).
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Tremper et al., "The Preoperative Treatment of Severely Anemic Patients with a Perfluorochemical Blood Substitute, Fluosol-DA 20%", Crit. Care Med. 8, p. 738, (1980).
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Abstract No. [85] Pool Rounds, (one p.).
Booklet, "William Harvey Introduces a New Geometry for Oxygen Performance."
State of the Art Symposium, "Artificial Blood", National Institutes of Health, Apr. 5-6, 1974, Federation Proceedings, vol. 34, No. 6, pp. 1428-1517, (1975).
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S. A. Gould et al., Fed. Proc. 40:2038, (1981).
Doss et al., Microvascular Research 13, pp. 253-260, (1977).
Lesmes George F.
Swisher Nancy A. B.
Thomas Jefferson University
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