Process for the preparation of .beta.-lactam antibiotics

Details Process for the preparation of .beta.-lactam antibiotics Process for the preparation of .beta.-lactam antibiotics

1981-06-03

1984-05-01

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602453, 2602391, 2602452T, 424270, 424271, C07D49900, C07D50104

Patent

active

044460694

ABSTRACT:
The present invention provides a process for the preparation of a fused bicyclic .beta.-lactam containing compound having an optionally salified free carboxylic acid group which process comprises the reaction of an ester of the formula (I): ##STR1## with halide ion; wherein R is the residue of the fused bicyclic .beta.-lactam containing compound, R.sup.1 is an alkyl group of 1-6 carbon atoms optionally substituted by an alkoxy group of 1-4 carbon atoms or is an optionally substituted phenyl group or an alkyl group of 1-4 carbon atoms substituted by an optionally substituted phenyl group; and R.sup.2 is a hydrogen atom or an alkyl group of 1-4 carbon atoms or is joined to R.sup.2 to form part of a 5- or 6- membered carbocyclic or heterocyclic ring.

REFERENCES:
patent: 4255332 (1981-03-01), Davies
patent: 4258050 (1981-03-01), Harbridge
patent: 4293555 (1981-10-01), Christensen et al.

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