Hydrogels of absorbable polyoxaesters

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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528272, 528301, 528361, 424426, 424430, 424433, 424444, 424446, 424448, 424486, 428 357, 428 358, 428 362, 428 98, 428221, 4283044, 428357, 428359, 428364, 428383, 4284231, 525437, 525509, 525511, A61F 220

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active

056982135

ABSTRACT:
The present invention describes a new crossslinkable and crosslinked aliphatic polyoxaesters and blends thereof that may be used to produce hydrogels, surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The crosslinked aliphatic polyoxaesters of the present invention are formed from an aliphatic polyoxaester a first divalent repeating unit of formula I: (R.sub.2)--C(O)--! I
and a second repeating unit selected from the group of formulas consisting of:
and
and combinations thereof. These aliphatic polyoxaesters may be blended with other polymers which are preferably biocompatible.

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patent: 4546152 (1985-10-01), Koelmel et al.
patent: 4552948 (1985-11-01), Barbee et al.
patent: 4689424 (1987-08-01), Shalaby et al.
patent: 4703069 (1987-10-01), Kolan et al.
patent: 4963641 (1990-10-01), Davis
patent: 5349028 (1994-09-01), Takahashi et al.
patent: 5464929 (1995-11-01), Bezwada et al.

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