Process for de-cyanoethylating blocked nucleotides

Details Process for de-cyanoethylating blocked nucleotides Process for de-cyanoethylating blocked nucleotides

1981-08-24

1983-12-06

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1512, C07H 1700

Patent

active

044195095

ABSTRACT:
A .beta.-cyanoethyl blocking group is selectively removed from the phosphate moiety of a nucleotide or polynucleotide by treatment with a primary amine having from 3 to 5 carbon atoms.

REFERENCES:
patent: 3284440 (1966-11-01), Patchett et al.
patent: 4310662 (1982-01-01), Crea
Adamiak, R. W., Barciszewska, M. Z., Biala, E., Grzeskowiak, K., Kierzek, R., Kraszewski, A., Markiewicz, W. T., and Wiewiorowski, M., Nucleic Acids Research 3, 3397-3408, (1976).
Sood, A. K., and Narang, S. A., Nucleic Acids Research 4, 2757-2765, (1977).

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