Ascorbic acid compositions for reducing irritation of topically

Details Ascorbic acid compositions for reducing irritation of topically Ascorbic acid compositions for reducing irritation of topically

1996-02-06

1997-12-30

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3134

Patent

active

057031223

ABSTRACT:
The use of an effective amount of ascorbic acid (Vitamin C) or one or more of its derivatives, has been found to decrease skin irritation caused by the topical administration of an active ingredient for treating a skin condition. Examples of the active ingredient include .alpha.-hydroxy acids, .beta.-hydroxy acids, keto acids, benzoyl peroxide, retinol (Vitamin A), retinoic acid, retinal A.sub.2, Vitamin A epoxide, lactamides and quaternary ammonium lactates, C.sub.4-12 hydroxylated carboxylic acids, sulfur, resorcinol and salicylic acid, and various derivatives thereof. The ascorbic acid (or its derivatives) is present in effective amounts from about 0.5% to about 25% by weight. It is provided by topical application of a separate solution or by admixture with a cosmetically or pharmaceutically acceptable vehicle for the active ingredient.

REFERENCES:
patent: 4983382 (1991-01-01), Wilmott et al.
patent: 5140043 (1992-08-01), Darr et al.
The Merck Manual, 5th Edition, 1987, Merck & Co., Rahway, NJ, pp. 2255, 2347-2350.
Sauer, Manual of Skin Diseases, 3rd Edition, 1973, J.B. Lippincott Co., Philadelphia, PA.

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