Inhibition of respiratory burst using posttranslational modifica

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514557, 514763, A61K 31015, A61K 3119, A61K 3135

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active

052449165

ABSTRACT:
The present invention relates to the use of posttranslational modification inhibitors, such as isoprenylation inhibitors, to inhibit activation of phagocyte NADPH oxidase and respiratory burst. Therapeutic compositions containing various inhibitors, and methods of using same, are also disclosed.

REFERENCES:
Curnutte, et al., J. Biol. Chem. 262: 6450-2 (1987).
Curnutte, et al., J. Biol. Chem. 262: 5563-5569 (1987).
Clark, J. Infect. Dis. 161: 1140-7 (1990).
Buss, et al., Mol. Cell. Biol. 11: 1523-1530 (1991).
Bokoch, et al., J. Cell. Biol. 106: 1927-1936 (1988).
Quinn, et al., Nature 342: 198-200 (1989).
Bokoch, et al., Science 254: 1794-6 (1991).
Gibbs, Cell 65: 1-4 (1991).
Knaus, et al., Science 254: 1512-1515 (1991).
Maltese, et al., J. Biol. Chem. 265: 2148-2155 (1990).
Maltese, FASEB 4: 3319-3328 (1990).
Hancock, et al., EMBO J. 10: 641.sub.]646 (1991).
Hancock, et al., Cell 57: 1167-1177 (1989).
Casey, et al., PNAS USA 86: 8323-8327 (1989).
Schafer, et al., Science 245: 379-384 (1989).
Jackson, et al., PNAS USA 87: 3042-3046 (1990).
Endo, et al., FEBS 72: 323-326 (1976).
Alberts, et al., PNAS USA 77: 3957-3961 (1985).
Elson, et al., Carcinogenesis 9: 331-2 (1988).
Crowell, et al., J. Biol. Chem. 266: 17679-17686 (1991).

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