Compositions and methods for dissolving body calculi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514642, 514643, A61K 3144, A61K 3114

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active

052449130

ABSTRACT:
Compositions and methods for dissolving calculi deposits in humans are disclosed. The compositions include solutions of quaternary ammonium salts and are particularly effective for the contact dissolution of pigment portions of biliary tract calculi such as gallstones. The solutions preferably further include mineral chelating agent and disulfide bond cleaving agent to aid in deaggregating mineral components and glycoprotein components of calculi.

REFERENCES:
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patent: 4423063 (1983-12-01), Rooney et al.
patent: 4759923 (1988-07-01), Buntin et al.
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"Solvents for Stone Dissolution: Pigment Stones", Leuschner, U. Digestion 39, 100-110, 1988.
"Contact Dissolution of `mixed` Gallstones: in vitro, MTBE Alternated with N-acetyl Cysteine is More Effective Than When Alternated with Bile Acid-EDTA", Dowling, Clinical Science, 79, Suppl. 1990.
"Dissolution of Human Brown Pigment Biliary Stones", Dai et al, Journal of Hepatology, 9, 301-311, 1989.
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"Addition of N-acetylcysteine to Aqueous Model Bile Systems Accelerates Dissolution of Cholesterol Gallstones", Niu et al, Gastroenterology, 98, 2, 454-463, 1990, Abstract.
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World Patent Index No. 83/748638/35, inventor C. Laruelle et al.
W. Swobodnik, "Local litholysis: Dissolution of calcified stones", p. 1, 1990.

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