Apparatus for performing tissue perfusion measurements

Details Apparatus for performing tissue perfusion measurements Apparatus for performing tissue perfusion measurements

1981-11-02

1984-05-01

Rosenbaum, C. Fred

Surgery

Truss

Pad

128635, A61B 500

Patent

active

044455151

ABSTRACT:
Apparatus and method are disclosed for monitoring the perfusion rate of a liquid through the tissue of a living animal. The apparatus and method involve contacting the tissue with an electrode probe and at least one sensor probe at a predetermined spaced relation to the electrode probe. A continuous electrical current is applied to the electrode probe to generate in situ in the tissue a gaseous substance the concentration of which may be measured by the sensor member. The electrical current is applied at a rate which maintains the concentration at a selected level, the perfusion rate being derived as a function of the quantum of electrical current required to be applied. The diffusion rate of the substance through the fluid may be mathematically derived through the use of additional sensor probes and the diffusion rate may be subtracted from the measured perfusion rate. In this manner a constant monitoring of perfusion rate is obtained.

REFERENCES:
patent: 4016863 (1977-04-01), Brantigan
patent: 4244713 (1981-01-01), Goodwin
"Chem. Abstracts", vol. 80, 1974, p. 187 Abstract #117800D.
"Naturwissenschaften", 1970, vol. 57, p. 311.
"Determination of Local blood Flow . . . ", Pflugers Arch. 348, pp. 225-238 (1974).
Akademie der Wissenschaften, Wodick, 1976, pp. 249-251 and 334-355.
"Evaluation of Local Tissue Blood Flow . . . ", J. Appl. Physiol, Levy et al.
"Thermodynamic Technique for the Quantification of Regional Blood Flow", Adams et al., Amer. J. of Physiol, 1980.
"Process Systems Analysis and Control", McGraw Hill, Coughanowr et al.

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