Immunotherapeutic imides/amides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514417, 5462771, 548476, A61K 3144, C07D20948

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active

057030987

ABSTRACT:
Imide/amide ethers and alcohols are inhibitors of cytokines including tumor necrosis factor .alpha. and can be used to combat cachexia, endotoxic shock, arthritis, asthma, and retrovirus replication. A typical embodiment is 3-Phthalimido-3-(3', 4'-dimethoxyphenyl)propan-1-ol.

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Ghassan S. Dbaibo et al. (Aug. 25, 1993) The Journal of Biological Chemistry, vol. 265 (24), pp. 17762-17766.
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Yuichiro J. Suzuki, et al. (May 28, 1993) Biochemical and Biophysical Research Communications, vol. 193 (1), pp. 277-283.
Yuichiro J. Suzuki et al. (Nov. 1993) Biochemistry and Molecular Biology International, vol. 31(4), pp. 693-700.

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