Preparation of a polymeric hydrogel containing micropores and ma

Details Preparation of a polymeric hydrogel containing micropores and ma Preparation of a polymeric hydrogel containing micropores and ma

1991-12-17

1993-09-14

Naff, David M.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

424487, 435174, 435180, 523106, 525937, 526328, 528310, C12N 500, C12N 1108, C08F 2010, C08G 6908

Patent

active

052447995

ABSTRACT:
A hydrophilic substituent of a bicontinuous cubic phase in equilibrium is polymerized and the unpolyermized components subsequently removed and replaced with water, creating a hydrogel which is locally highly cross-linked but of high water content because of the presence of a periodic network of water-filled macropores superposed on the hydrogel matrix. The diameter of these "macropores" can be preselected between 20 Angstroms and several hundred Angstroms or even higher, and in general will be much larger than the "micropores" within the hydrogel portions of the final material. The material has high water content, good mechanical integrity and notch strength, high permeability to oxygen, and the pore size can be chosen to allow passage of molecules of pre-selected size. The material is useful as a cell culture substrate and in a contact lens and other biological and medical applications.

REFERENCES:
patent: 3860490 (1975-01-01), Guttag
patent: 4519909 (1985-05-01), Castro

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