Method of preparing fibronectin and antihemophilic factor

Details Method of preparing fibronectin and antihemophilic factor Method of preparing fibronectin and antihemophilic factor

1980-03-05

1982-07-27

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112R, 424177, A61K 3514

Patent

active

043417647

ABSTRACT:
Methods are disclosed for obtaining fibronectin and antihemophilic factor in commercial quantities from blood plasma. In the disclosed methods a blood plasma fraction containing fibronectin and antihemophilic factor is isolated from blood plasma and then solubilized in an aqueous medium. The solution is acidified and chilled at a temperature sufficient to form an acid-chill precipitate containing a major proportion of the fibronectin and a solution containing a major proportion of the antihemophilic factor of the blood plasma fraction. Fibronectin and antihemophilic factor are then isolated respectively from the precipitate and solution.

REFERENCES:
patent: 4210580 (1980-07-01), Amrani
Vuento-Biochem. J.-vol. 183, (Nov. 1979), pp. 331-333 & 336.
Stathakis-Chem. Abst., vol. 89, (1978), p. 18609c.
Rock et al.-Chem. Abst., vol. 93, (1980), pp. 155,766y.

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