Substituted naphthyridinones and processes for their preparation

Details Substituted naphthyridinones and processes for their preparation Substituted naphthyridinones and processes for their preparation

1978-10-23

1980-10-21

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544127, 546122, 546123, 546193, 4242485, 42424857, C07D40302, A61K 3144

Patent

active

042294568

ABSTRACT:
Organic chemical compounds based upon the naphthyridine molecule are disclosed which have potent gastric secretion inhibitory properties. The naphthyridinone is substituted with a substituted amino alkyl group at the 1-position, and variously substituted at the remaining positions. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

REFERENCES:
patent: 3429887 (1969-02-01), Lesher
patent: 3590036 (1971-06-01), Lesher et al.
patent: 3673193 (1972-06-01), Lesher et al.
patent: 4133885 (1979-01-01), Bolhofer et al.
Hawes et al. (I), J. Chem. Soc. C (Org.), 1966, pp. 315 to 321.
Hawes et al. (II), J. Chem. Soc. C (Org.), 1967, pp. 1564 to 1567.
Allen, Chem. Reviews, vol. 47, p. 295 (1950).
Oae, Organic Chemistry of Sulfur, p. 196, Plenum Press (NY) 1977.
English et al., Principles of Organic Chemistry, p. 334, McGraw-Hill Book Co. Inc., NY (1949).
Klingsberg, Pyridine and Its Derivatives, Part Three, p. 651, Interscience Pulbishers (1962).

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