Method for reparing an amorphous sulfonamide

Details Method for reparing an amorphous sulfonamide Method for reparing an amorphous sulfonamide

1995-03-13

1996-04-02

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20914

Patent

active

055042163

ABSTRACT:
The invention provides a pharmaceutical composition comprising a particular physical form of N- 4- 5-(cyclopentyloxy-carbonyl)amino-1-methylindol-3-yl-methyl!-3-methox ybenzoyl!-2-methylbenzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N- 4- 5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl!-3-methoxy benzoyl!-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.

REFERENCES:
Haleblian, J. et al. "Pharmaceutical Applications of Polymorphism", J. Pharmaceutical Sciences, vol. 58 No. 8, Aug. 1969, pp. 911-929.

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