Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase

Details Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase

1992-12-14

1993-12-07

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25330

Patent

active

052684989

ABSTRACT:
The bisulfite adduct of a carbonyl compound, amine, and alkali metal cyanide are reacted in aqueous media to form an organic layer containing the desired .alpha.-aminonitrile product and an aqueous layer containing alkali metal sulfite. The aqueous layer, after separation from the organic layer, can be used as the reaction medium in a fresh reaction of bisulfite adduct, amine and alkali metal cyanide after its pH has been adjusted to the moderately acidic range, e.g., a pH of about 4 to about 5.

REFERENCES:
patent: 2164781 (1939-07-01), Platz et al.
Rappoport, "The Chemistry of the Cyano Group," (1970), pp. 74-75.
"The Merck Index" (1983), 10th Ed., p. ONR-87.
Hauser, et al.; J.A.C.S., 82 (1960), pp. 1786-1789.
Luten, Jr.; J. Org. Chem., 3 (1938-1939) pp. 588-597.
D. T. Mowry, "The Preparation of Nitriles", (1948), Chemical Reviews vol. 42, pp. 189, 238, 270-271, 279,281.
Y. M. Shatran et al., "Synthesis and Properties Of .alpha.-Aminonitriles", Russian Chemical Reviews 58(2) 148-162 (1989).

Affiliated with

Also associated with

Rating

Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis-of .alpha.-aminonitriles with recycle of aqueous phase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2017013