Pharmacologic preparation for the treatment of anal disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing compound doai

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514470, 514740, 514171, 514179, 514312, 514882, A61K 3104

Patent

active

055041175

ABSTRACT:
A medical preparation for treating anal disorders comprises an effective amount of a nitric oxide donor, preferably an organic nitrate. The preparation may be in the form of an ointment that is applied to affected tissue at least once daily.

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patent: 5183663 (1993-02-01), Greiner
Rattan et al., "Nitric Oxide Pathway in Rectoanal Inhibitory Reflex of Oppossum Internal Anal Sphincter," Gastroenterology, vol. 103, pp. 43-50, 1992.
Rattan et al., "Role of Nitric Oxide as a Mediator of Internal Anal Sphincter Relaxation," from article Nitric Oxide as Gut Smooth Muscle Inhibitory Mediator, American Journal of Physiology, pp. G107-G112, 1992.
O'Kelly et al., "Nerve Mediated Relaxation of the Human Internal Anal Sphincter: The Role of Nitric Oxide," Gut, vol. 34, pp. 689-693, 1993.
Chakder et al., "Release of Nitric Oxide by Activation of Nonadrenergic Noncholinergic Neurons of Internal Anal Sphincter," American Journal Physiology, vol. 264, pp. G7-G12, 1993.
Loder et al., "Reversible Chemical Sphincterotomy by Local Application of Glyceryl Trinitrate," British Journal of Surgery, vol. 81, pp. 1386-1389, 1994.
Schouten, et al., "Pathophysiological Aspects and Clinical Outcome of Intra-anal Application of Isosorbide-di-Nitrate in Patients with Chronic Anal Fissure", Dis Colon Rectum, Apr., 1985, p. 18.
Loder, et al., "Topical Application of a Nitric Oxide Donor Reduces Internal Anal Sphincter Tone: Therapeutic Implications" Gastroenterology, 93 104 A544, Apr., 1993 (Abstract).
Loder, et al., "Topical Application of a Nitric Oxide Donor Reduces Internal Anal Sphincter Tone: Therapeutic Implications", Gut 1993, 34 S25, Apr., 1993. (Abstract).
Jensen, "Treatment of First Episodes of Acute Anal Fissure: Prospective Randomised Study of Lignocaine Ointment Versus Hydrocortisone Ointment or Warm Sitz Baths Plus Bran", 1986, Br. Med. J. 292 (6529) 1167-9.
Watson, et al. "Glyceryl Trinitrate and Anal Fissure: Resistance to Endogenous Nitric Oxide and Tachyphylaxis", Diseases of the Color & Rectum, vol. 38, No. 4, Apr., 1995, p. 29.

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