N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox

Details N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of ox

1995-04-17

1996-04-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, A61K 3142, A61K 31425

Patent

active

055040977

ABSTRACT:
This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or C.sub.1 -C.sub.6 trifluoroalkoxy;

REFERENCES:
Nagano, Arteriosclerosis 9 (4) 453 (1989) .

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