Method of production and use of microbubble precursors

Details Method of production and use of microbubble precursors Method of production and use of microbubble precursors

1986-04-22

1987-07-21

Coven, Edward M.

Surgery

Truss

Pad

A61B 1000

Patent

active

046811192

ABSTRACT:
In the inventive method, microbubbles are formed in body liquid or carrier liquid, for example within the genitourinary or digestive systems in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

REFERENCES:
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4615879 (1986-10-01), Runge et al.

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