Retrovirus detection

Details Retrovirus detection Retrovirus detection

1993-08-13

1996-04-02

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 721, 435 724, C12Q 170, G01N 33567, G01N 3353, G01N 33555

Patent

active

055039740

ABSTRACT:
A method, and groups of cells and retroviruses useful in the performance of the method, of testing for the presence or amount of a first retrovirus in a specimen. A replication defective retroviral construct having a marker sequence is exposed to the specimen and the presence or amount of a recombinant retrovirus carrying the marker sequence is tested for. The replication defective vector may be disposed in cells, with the specimen being tested for the presence or amount of a retrovirus, or it may be disposed in a retrovirus, with the specimen being a group of cells which are tested for the presence or amount of said first retrovirus. In either case, where a first retrovirus complements the defective vector, a recombinant retrovirus carrying the marker sequence will be produced. The first retrovirus to be tested for may be of a previously known, or unknown type, and may be any of a group of retroviruses.

REFERENCES:
Gruber, et al, 1985, "Retroviral Vector-Mediated Gene Transfer . . . " Science 230: 1057-1061.
Stierle, et al, 1987, "Parvovirus Associated Antigen in the . . . " Annals Rheum. Disease 46:219-223.
Miller, et al, 1986, "Redesign of Retrovirus Packaging . . . " Mol. & Cell. Biol. 6(8): 2895-2902.
Milewski, Recombinant DNA Technical Bulletin, 9(2):88 (1986).
Ledley, F., The Journal of Pediatrics, 110(1):1 (1987).
Callahan et al., Science, 228:1208 (1985).
Annals of the Rheumatic Diseases, 46:219-223 (1987).
Bardwick et al., Arthritis Rheum., 23:626 (1980).
Brassfield et al., Arthritis Rheum., 25:930 (1982).
Weiss, R., RNA Tumor Viruses, vol. I, pp. 209-260 (Cold Spring Harbor Laboratory, New York).
Eckner and Ketrick, J. of Virology, 24:383-390 (1979).
Norval et al., Ann. Rheum. Dis. 38:507 (1979).
Hart et al., Ann. Rheum. Dis., 38:514 (1979).
Broder et al., Ann. Rev. Immunol., 3:321 (1985).
Gruber et al., Science 230:1057-1061 (1985).
Miller et al., Proc. Natl. Acad. Sci.USA, 80:4709-4713 (1983).
Yee, J. K., Gene 53:97-104 (1987).
Mann et al. Cell 33:153-159 (1983).
Watanabe et al., Molecular and Cellular Biology 3(12):2241-2249 (1983).
Watanabe et al., Proc. Natl. Acad. Sci. USA 79:5986-5990 (1982).
Watanabwe et al., Eukaryotic Viral Vectors, pp. 115-121, edited by Y. Gluzman, cold Spring Harbor Laboratory, NY, USA (1982).
Linial, J. of Virology 38(1);380-382 (1981).
Miller and Buttimore, Molec. Cell Biol. 6:2895-2902 (1986).
Willis et al., J. Biol. Chem. 259:7842-7849 (1984).
Miller et al., Molec. Cell Biol. 5:431-437 (1985).
Price, J., et al. Proc. Natl. Acad. Aci. USA , 84:156-160 (1987).
Kunkel, T., Proc. Natl. Acad Sci. USA 82:448 (1985).
Journal of General Virology, vol. 67, part 7, issued Jul. 1986, W. Ostertag et al., "The Myeloproliferative Sarcoma Virus Retains Transforming Functions after Introduction of a Dominant Selectable Marker Gene", pp. 1361-1371 . See Abstract p. 1361.

Affiliated with

Also associated with

Rating

Retrovirus detection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Retrovirus detection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retrovirus detection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2015699