Process and intermediates for the preparation of excitatory amin

Details Process and intermediates for the preparation of excitatory amin Process and intermediates for the preparation of excitatory amin

1992-11-18

1995-11-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, 546142, C07D21724, C07D21726, C07D21714, C07D21718

Patent

active

054709784

ABSTRACT:
The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activity.

REFERENCES:
patent: 4902695 (1990-02-01), Ornstein
Stephen R. Wilson et al., "The Cinchona Alkaloids: . . . ", J. Org. Chem. 1991, vol. 56, 4766-4772.
S. Wattanasin, et al., J. Org. Chem., 1985, 50, 3810.
S. F. Martin, et al., J. Org. Chem., 1983, 48, 5170.
T. Moriwake, J. Org. Chem., 1989, 54, 4114.
Melikian-Badalian and Ornstein, LRL News, Mar. 1992, p. 31.
J. Levy, et al., Tetrahedron Letters, 1988, 29, 3303.
European Search Report , Feb. 7, 1994, Application No. 93309004.5.

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