14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives

Details 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives

1993-03-19

1995-11-28

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 72, 536 73, C07J 1708, A61K 3170

Patent

active

054709610

ABSTRACT:
Disclosed are (1) a structurally novel 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.

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Sasaki et al. The Journal of Antibiotics, vol. 41(7), pp. 908-915, (1988).
Tsuzuki, Kazuo, Chem. Pharm. Bull 37(10) 2687-2700 (1989).
Omura, Satoshi, et al., Journal of Medicinal Chemistry, vol. 30:11 1941-1943 (1987).

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